Pregnenolone is not a steroid but a steroid hormone precursor manufactured in the body from cholesterol. Pregnenolone is converted in the liver to DHEA (dehydroepiandrosterone) and progesterone (and ultimately other hormones such as estrogen and testosterone). It is important to note that as we age the body’s natural pregnenolone levels decrease. Therefore, supplemental pregnenolone may play an important role in today’s aging population supporting lean body mass, strength, immune health as well as bone and cardiovascular health.
Pregnenolone is synthesized from cholesterol. This conversion involves hydroxylation at the side-chain at C20 and C22 positions, with cleavage of the side-chain. The enzyme performing this task is cytochrome P450scc, located in the mitochondria, and controlled by anterior pituitary tropic hormones, such as adrenocorticotropic hormone, follicle-stimulating hormone and luteinizing hormone.
Pregnenolone can be converted to 17-hydroxy-pregnenolone by the enzyme 17α-hydroxylase (CYP17A1). Using this pathway, termed delta-5 pathway, the next step is conversion to dehydroepiandrosterone (DHEA) using a desmolase. DHEA is the precursor of androstenedione.
Pregnenolone and its sulfate, like DHEA and its sulfate and progesterone, belong to the group of neuro-steroids that are found in high concentrations in certain areas of the brain, and are synthesized there. Since pregnenolone is a precursor to DHEA, its balance in the body helps to support memory and cognition, joint health, energy, fatigue reduction, cholesterol balance and wellness and mood.
What is the daily suggested use?
Take 1 capsule daily with a meal, or as directed by your qualified healthcare provider
What is the safe age for people to use this product?
This product has been formulated for use by adults ages 18 and older.
Is this product safe for consumption while pregnant or nursing?
This product is not suitable for use by pregnant or breastfeeding women.
Disclaimer: If you are pregnant or nursing MRM does recommend informing your healthcare provider of any supplement you take or plan to take.
Is this ingredient micronized?
Yes this ingredient is micronized to help absorption.