|TeaCrine™ (Theacrine), also known as 1,3,7,9-tetramethyluric acid, is a purine alkaloid found in Theobroma grandiflorum and in a Chinese tea known as “ku cha”. Research has shown teacrine to support inflammatory balance and relief and appears to affect adenosine signaling in a manner similar to caffeine.
TeaCrine™ in synthesized from caffeine in what is thought to be a three-step pathway. TeaCrine™ is a groundbreaking compound that supports “Clean Energy”.
While the ingredient falls into the same class of molecular compounds as caffeine, one of the unique attributes is the diminished adaptation or sensitization phenomena. Multiple studies with animal models have reported additional benefits beyond the typical neurochemistry of caffeine, such as improved alertness, locomotion (improved mobility) and neural drive, analgesia (reduced sensation of discomfort) and liver support. It also appears to act on both adenosinergic and dopaminergic pathways assisting multiple neurochemical pathways.
Preliminary data support the benefits of acute TeaCrine™ supplementation on subjective “energy” levels and some indices of mental performance. Future studies are underway to confirm these neurotropic effects and also explore potential benefits of TeaCrine™ on objective measures of cognitive and physical performance, inflammation, pain perception, and functional capacity.
For years, scientists were only aware of the function of ATP within the cell (intracellular). In the 1980s, a major breakthrough in ATP research was achieved when it was discovered that ATP has a major role outside the cell (extracellular) as well. Purinergic receptors that accept ATP are embedded in the plasma membrane of the cell. ATP acts as a signaling molecule directly upon these receptors, where it controls numerous metabolic reactions, including muscular excitability, vasodilation, and anabolic signaling.
PEAK ATP® increases levels of extracellular ATP supporting muscular excitability. Muscular fatigue is caused by a decrease in muscular excitability, or the muscle’s ability to respond rapidly to a stimulating agent telling the muscle to contract. That stimulating agent is calcium.
Unfortunately, exercise depletes calcium from muscle cells, causing a decrease in muscular excitability and an increase in fatigue. In fact, a 50% decrease in calcium can result in an 80% reduction in force. The key to fighting muscular fatigue is to increase muscular excitability. Increases in muscular excitability lead to an increase in the intensity of muscle contractions. Extracellular ATP boosts levels of calcium and glucose within the cells. When intracellular calcium levels rise, there is also an increase in the number of muscle filaments binding and the velocity at which these muscle filaments slide to create a contraction. These two factors directly impact muscle strength and power. ATP also stimulates protein synthesis, helping build new muscle tissue.
In addition to muscle excitability and anabolic support, extracellular ATP causes capillaries to synthesize and release nitric oxide (NO) and endothelial derived hyperpolarizing factor (EDHF), supporting healthy blood flow. Healthy blood flow facilitates the delivery of oxygen and nutrients to the cells and the removal of metabolic waste, benefiting nearly every tissue in the body.